Chukwuenweniwe J Eboka,
Henry A Okeri
,
For correspondence:- Henry Okeri Email: hokeri1@yahoo.com Tel: +2348023112394
Published: 30 December 2014
Citation: Eboka CJ, Okeri HA, Thermodynamics of the Solubility of Some Fluoroquinolones in n-Butanol. J Sci Pract Pharm 2014; 1(1):37-40 doi: 10.47227/jsppharm.v1i1.8
© 2014 The author(s).
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Purpose: This study was to investigate the solubility and determine the thermodynamic parameters of solubility of three fluoroquinolones in an organic solvent (n-butanol) so as to establish their correlation with their transfer (absorption and penetration of bacterial cell wall) processes.
Methods: The solubility of the three fluoroquinolones in n-butanol at different temperatures of 20 oC, 25 oC, 30 oC, 37 oC and 45 oC,was determined using UV-visible spectrophotometryat their appropriate wavelengths of maximum absorption.
Results: The results showed that the solubility of the fluoroquinolones in n-butanol increased with increasing temperature. Of the three fluoroquinolones studied, norfloxacin was the most soluble in n-butanol.
Conclusion: The solubilization process of these fluoroquinolones in n-butanol was non-spontaneous
